How big is the hole?
In an earlier post I likened the production of a protein with a new function to a blind man playing golf. One commenter wondered how large the hole was. I thought of this again while reading Stephen Meyer's recent book "Signature in the Cell". He presents the figure of 1 out of 10^74 as the number of possible proteins 150 amino acids long which have any function whatsoever. If this is correct then the hole is very small indeed...roughly equivalent to finding a single marked atom blindfold from all the atoms in the milky way. This figure also assumes that all the amino acids are left handed and only peptide bonds are formed.