Back to the Golf Course.
Some readers did not "get" my golf course analogy. I find it helpful to clarify my thinking so I will have another go to explain it.....
Imagine a 2-dimensional protein gel for a particular protein.
Imagine that a change in its amino acid sequence will change it’s position on the gel.
Thus for a 150 amino acid protein there are 20^150 positions spread out to cover a wide area on the gel.
Then imagine for each variant of that protein you can measure its “selective advantage” for a particular organism.
Then imagine you can plot these selective advantages on the 2-Dimensional gel to give a “contour” map of the protein’s functionality.
Then imagine that the current structure and function of the protein is the hole in a golf course and the contour map that you have is the terrain of the golf course with the selective advantages going downwards towards the hole.
As I said in this post the two models of protein function origin look for different contour maps for protein functionality.
The RMNS model would hope to find a large catchment area for protein functionality. The ID model would hope to find a sharp distinction between function and no function with relatively few variants having a function.
To understand the IC argument you have to imagine several of these golf courses being played independently with the requirement that the protein golf ball on each golf course arrives in its respective hole at the same time.